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  Indian J Med Microbiol
 

Figure 1: (a) Genome organization of severe acute respiratory syndrome coronavirus-2 isolates from Gujarat and Karnataka. (b) Genome organization of severe acute respiratory syndrome coronavirus-2 isolates from Kerala. The genome organization consists of untranslated region at its 5' and 3' end. 5' untranslated region is followed by open reading frame-1ab which encodes for nonstructural proteins (nsp) as a single polyprotein which later on cleaved into individual nsps. Nsps are essential for replication of severe acute respiratory syndrome coronavirus-2. Structural proteins encoded are Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N) which are indicated. Severe acute respiratory syndrome coronavirus-2 genome also contains open reading frames 3a, 6, 7a, 7b, 8, and 10. Open reading frame-7b is present only in Gujarat and Karnataka isolates and absent in isolates from Kerala.

Figure 1: (a) Genome organization of severe acute respiratory syndrome coronavirus-2 isolates from Gujarat and Karnataka. (b) Genome organization of severe acute respiratory syndrome coronavirus-2 isolates from Kerala. The genome organization consists of untranslated region at its 5' and 3' end. 5' untranslated region is followed by open reading frame-1ab which encodes for nonstructural proteins (nsp) as a single polyprotein which later on cleaved into individual nsps. Nsps are essential for replication of severe acute respiratory syndrome coronavirus-2. Structural proteins encoded are Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N) which are indicated. Severe acute respiratory syndrome coronavirus-2 genome also contains open reading frames 3a, 6, 7a, 7b, 8, and 10. Open reading frame-7b is present only in Gujarat and Karnataka isolates and absent in isolates from Kerala.