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CASE REPORT
Year : 2020  |  Volume : 64  |  Issue : 1  |  Page : 93-95

Sickle cell disease presenting in the third trimester of pregnancy: Delayed detection heralding a public health problem?


1 Senior Resident, Department of Pathology, Lady Hardinge Medical College, New Delhi, India
2 Assistant Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India
3 Associate Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India
4 Director Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India

Correspondence Address:
Kavita Gaur
Department of Pathology, Lady Hardinge Medical College, Shaheed Bhagat Singh Marg, New Delhi - 110 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijph.IJPH_223_19

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We report the case of a 22-year-old primigravida detected as having sickle cell disease (SCD), initially presenting in the third trimester (30th week) of pregnancy. The patient came to our center with a complaint of severe lower limb pain. The peripheral smear showed marked anisopoikilocytosis, numerous leptocytes, sickle cells, and target cells. High-performance liquid chromatography corroborated the diagnosis of SCD, showing a significant peak in the sickle window. The patient was conservatively managed and delivered a healthy baby through normal vaginal delivery. Delayed presentation of SCD in the third trimester of pregnancy is unusual. This report aims to bring attention to the possible causes of such a lag in detection. We also suggest measures to refine the antenatal healthcare screening at multiple levels, with regard to the detection of sickle cell hemoglobinopathy.


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