Indian Journal of Public Health

ORIGINAL ARTICLE
Year
: 2004  |  Volume : 48  |  Issue : 2  |  Page : 70--77

The BCG controversy : a reappraisal of the protective effect against tuberculosis and leprosy.


SP Zodpey 
 Clinical Epidemiology Unit, and Department of Preventive and Social Medicine, Government Medical College, Nagpur, Maharashtra, India

Correspondence Address:
S P Zodpey
Clinical Epidemiology Unit, and Department of Preventive and Social Medicine, Government Medical College, Nagpur, Maharashtra, India

BCG (Bacillus Calmette Guerin) vaccine remains a highly controversial method of preventing tuberculosis and leprosy despite more than eighty years of use. The protective effect against tuberculosis observed in various studies ranged from -56% to 98%. Case-control studies carried out at Nagpur reported moderate effectiveness of BCG vaccination in prevention of tuberculosis. Its effectiveness was higher against extra-pulmonary tuberculosis. The summary protective effects obtained from meta-analysis of trials, cohort studies and case-control studies of BCG vaccination and tuberculosis were 51 (33-64), 76 (63-85), and 65 (57-72) percent respectively. The case-control studies carried out at Nagpur also demonstrated a significant protective association between BCG vaccination and leprosy. The summary protective effects obtained from meta-analysis of trials, cohort studies and case-control studies of BCG vaccination and leprosy were 43 (27-55), 62 (53-69), and 59 (46-68) percent respectively. The results of the current study and systematic review thus supported arguments favoring use of BCG vaccine for prevention of tuberculosis and leprosy.


How to cite this article:
Zodpey S P. The BCG controversy : a reappraisal of the protective effect against tuberculosis and leprosy. Indian J Public Health 2004;48:70-77


How to cite this URL:
Zodpey S P. The BCG controversy : a reappraisal of the protective effect against tuberculosis and leprosy. Indian J Public Health [serial online] 2004 [cited 2020 Jul 14 ];48:70-77
Available from: http://www.ijph.in/article.asp?issn=0019-557X;year=2004;volume=48;issue=2;spage=70;epage=77;aulast=Zodpey;type=0