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ORIGINAL ARTICLE
Year : 2007  |  Volume : 51  |  Issue : 3  |  Page : 184-189

Scar size and effectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of tuberculosis and leprosy: A case-control study


1 Professor, Preventive and Social Medicine & Faculty, Clinical Epidemeology Unit, Government Medical College, Nagpur, India
2 Lecturer, Mocrobiology, TB and Chest Diseases, Government Medical College, Nagpur, India
3 Formerly Dean, TB and Chest Diseases, Government Medical College, Nagpur, India
4 Formerly Asso. Professor, TB and Chest Diseases, Government Medical College, Nagpur, India

Correspondence Address:
Sanjoy P Zodpey
Professor, Preventive and Social Medicine & Faculty, Clinical Epidemeology Unit, Government Medical College, Nagpur
India
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Source of Support: None, Conflict of Interest: None


PMID: 18229442

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Background: The study was undertaken to estimate the effectiveness of BCG vaccination in relation to scar size in the prevention of tuberculosis and leprosy. Methods: The present study was designed as hospital-based pair-matched case-control study and was carried out at Government Medical College Hospital, Nagpur, Maharashtra, India. It included 877 cases of tuberculosis and 292 cases of leprosy (diagnosed by WHO criteria), born onwards 1962. Each case was pair-matched with one control for age, sex and socio-economic status. BCG vaccination status was assessed by examination for the presence of BCG scar, immunisation records if available and information from subjects/parents of children. Subjects uncertain about BCG vaccination were not included. The diameter of the BCG scar was measured both across and along the arm in millimeters using a plastic ruler. The average was then calculated. Results: A significant protective association between BCG vaccination and tuberculosis (OR=0.38, 95% Cl 0.31-0.47) and leprosy (OR = 0.38, 95% Cl 0.26-0.55) was observed. The overall vaccine effectiveness (VE) was 62% (95% Cl 53-69) against tuberculosis and 62% (95% Cl 45- against leprosy. Vaccine effectiveness against tuberculosis and leprosy was non-significantly greater in the group who had BCG scar size < 5 mm as compared to subjects who had BCG scar size > 5 mm. Thus there was no clear association between BCG scar size and its effectiveness. Conclusion: The current study did not identify any significant association between BCG scar size and its effectiveness against tuberculosis or leprosy.


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