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ORIGINAL ARTICLE
Year : 2007  |  Volume : 51  |  Issue : 2  |  Page : 91-96

Evaluation of a new premedication protocol for administration of equine rabies immunoglobulin in patients with hypersensitivity


1 Principal and Professor of Community Medicine, Kempegowda Institute of Medical Sciences, Bangalore, India
2 Professor and Head of Anesthesiology, Kempegowda Institute of Medical Sciences, Bangalore, India
3 Post-Graduate Trainee cum Tutor, Kempegowda Institute of Medical Sciences, Bangalore, India
4 Associate Professors, Kempegowda Institute of Medical Sciences, Bangalore, India
5 Professor & Head, Community Medicine, Kempegowda Institute of Medical Sciences, Bangalore, India

Correspondence Address:
M K Sudarshan
Principal and Professor of Community Medicine, Kempegowda Institute of Medical Sciences, Bangalore
India
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Source of Support: None, Conflict of Interest: None


PMID: 18240468

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Objectives: The present study was undertaken to standardize skin testing and to develop a safe and effective premedication protocol for administration of ERIG in those with skin test positivity/hypersensitivity. Methods: A method of grading of skin testing was developed using injection histamine as a positive control. This was evaluated by using it on 517 subjects who had severe (WHO category III) exposure to rabies. A premedication protocol consisting of injections pheniramine, ranitidine, hydrocortisone and adrenaline was evaluated by using it on fifty one subjects who were skin test positive/hypersensitive to ERIG. Results: The premedication protocol was safe and effective as all the S l subjects could be administered the full dose of ERIG despite being skin test positive/hypersensitive to ERIG. Besides the premedication drugs/protocol did not affect the immune response to vaccine and ERIG therapy.


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