Users Online: 822 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
 

 

Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
     
ORIGINAL ARTICLE
Year : 2004  |  Volume : 48  |  Issue : 2  |  Page : 70-77

The BCG controversy : a reappraisal of the protective effect against tuberculosis and leprosy.


Clinical Epidemiology Unit, and Department of Preventive and Social Medicine, Government Medical College, Nagpur, Maharashtra, India

Correspondence Address:
S P Zodpey
Clinical Epidemiology Unit, and Department of Preventive and Social Medicine, Government Medical College, Nagpur, Maharashtra, India

Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 15709589

Rights and PermissionsRights and Permissions

BCG (Bacillus Calmette Guerin) vaccine remains a highly controversial method of preventing tuberculosis and leprosy despite more than eighty years of use. The protective effect against tuberculosis observed in various studies ranged from -56% to 98%. Case-control studies carried out at Nagpur reported moderate effectiveness of BCG vaccination in prevention of tuberculosis. Its effectiveness was higher against extra-pulmonary tuberculosis. The summary protective effects obtained from meta-analysis of trials, cohort studies and case-control studies of BCG vaccination and tuberculosis were 51 (33-64), 76 (63-85), and 65 (57-72) percent respectively. The case-control studies carried out at Nagpur also demonstrated a significant protective association between BCG vaccination and leprosy. The summary protective effects obtained from meta-analysis of trials, cohort studies and case-control studies of BCG vaccination and leprosy were 43 (27-55), 62 (53-69), and 59 (46-68) percent respectively. The results of the current study and systematic review thus supported arguments favoring use of BCG vaccine for prevention of tuberculosis and leprosy.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed307    
    Printed27    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    
    Cited by others 4    

Recommend this journal