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Year : 1985  |  Volume : 29  |  Issue : 3  |  Page : 206-9

Poliomyelitis surveillance in Delhi.


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S Khare


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Source of Support: None, Conflict of Interest: None


PMID: 3835138

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This article summarizes laboratory analyses of serum samples collected at New Delhi's Kalawati Saran Children's Hospital, a center for research on poliomyelitis. The analysis of 1462 serum samples processed for antibody level against polio types 1, 2, and 3 in primary monkey kidney cell lines indicated a predominance of type 1 infection in New Delhi until 1978 and after 1981; in the interim period, type 2 predominated. In addition, seroconversion studies were carried out after 3 and 5 doses of oral polio vaccine. The seroconversion rates for types 1, 2, and 3 polio were 63%, 75%, and 75%, respectively, after 3 doses and 89%, 94%, and 97%, respectively, after 5 doses. Seroconversion rates were significantly higher in the winter than in the summer months. Analysis of 1652 cases of polio in 1977-81 in which children had been vaccinated revealed an overall polio prevalence rate of 6.2/1000 after the 1st dose, 3.2/1000 after the 2nd dose, and 4.7/1000 after the 3rd dose. A further analysis of 36 serum samples collected from normal adults found that only 4 samples were negative to antibodies against all 3 types of polio virus. Finally, random testing of the potency of oral polio vaccine batches has indicated that all have a satisfactory titer. A 1981 survey of 24,840 children in Delhi 5-9 years of age found a poliomyelitis prevalence rate of 5.88/1000; the onset of disease was 3 years of age and under in 82% of cases.


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